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KMID : 0914820040040020082
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Journal of the Korean Gastric Cancer Association
2004 Volume.4 No. 2 p.82 ~ p.88
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Expression of E-cadherin and CD44H in Borrmann Type Ⅳ Gastric Cancer
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Yook Jeong-Hwan
Choi Won-Yong
Shin Dong-Gyeu
Kim Yong-Jin
Kim Jung-Sun
Oh Sung-Tae
Kim Byung-Sik
Park Kun-Choon
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Abstract
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Purpose: E-cadherin and CD44H have been shown to play a role in the progression and the metastasis of tumors. This study evaluated the clinical correlations between expression of E-cadherin and CD44H and various clinicopathologic´ factors and the value of expressions of E-cadherin´ and CD44H as prognostic factors in Borrmann type IV gastric cancer.
Materials and Methods: In 122 patients with Borrmann type IV gastric cancer, we performed the immunohistochemical stainings for E-cadherin and CD44H. We analyzed the, correlation between the expressions of E-cadherin and CD44H and lymphatic invasion, venous invasion, perineural invasion, histologic type, lymph node metastasis, depth of invasion, stage, and peritoneal dissemination, and survival.
Results: There were no correlations between reduced expression of E-cadherin and CD44H and lymphatic´ invasion, venous invasion, perineural invasion, histologic type, lymph node metastasis, depth of invasion, and stage. However, there was a significant correlation between lymph, node metastasis and the lymphatic invasion (P=0.022). There was also a significant correlation between the peritoneal dissemination and CD44H expression (P=0.005). The 5-year survival rate was correlated with CD44H ex-pression (P=0.026), peritoneal dissemination (P<0.01), depth of invasion (P<0.01), lymph node metastasis (P< 0.01), stage of tumor (P<0.01), and lymphatic invasion (P <0.01). There was no correlation between expression of E-cadherin and survival rate.
Conclusion: The expression of CD44H and peritoneal dissemination was correlated. The expression of CD44H was an independent prognostic factor in Borrmann type IV gastric! cancer. Further prospective studies with a large number of cases are required.
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KEYWORD
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Borrmann type Ⅳ gastric cancer, E-cadherin, CD44H, Immunohistochemical staining
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